Targeting Acute and Chronic Toxoplasmosis

Grant number: 1123218 | Funding period: 2017 - 2020

Completed

Abstract

One third of the world's population is infected with the protozoan parasite, Toxoplasma gondii, which can cause life-threatening infections. This proposal will utilize new analytical technologies to understand how these parasites are able to survive in a wide variety of different host cells, how they manage to persist within brain and muscle tissue for the life of the patient and how infection may be linked to mental health disorders, such as schizopohrenia.

Related publications (2)

Protein kinase A negatively regulates Ca 2 signalling in Toxoplasma gondii

AD Uboldi, ML Wilde, EA McRae, RJ Stewart, LF Dagley, L Yang, NJ Katris, SV Hapuarachchi, MJ Coffey, AM Lehane, CY Botte, RF Waller, AI Webb, MJ McConville, CJ Tonkin

2018-09-01

The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stag..

Comparative metabolomics of mycoplasma bovis and mycoplasma gallisepticum reveals fundamental differences in active metabolic pathways and suggests novel gene annotations

Y Masukagami, DP De Souza, S Dayalan, C Bowen, S O'Callaghan, K Kouremenos, B Nijagal, D Tull, KA Tivendale, PF Markham, MJ McConville, GF Browning, FM Sansom

2017-09-01

Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a h..

University of Melbourne Researchers

Malcolm McConville